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. 2009 Sep 23;4(9):e7157. doi: 10.1371/journal.pone.0007157

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A 1000-bp region (Panel a) has been sequenced for select population samples. Upper case letters are cDNA sequences (part of the open reading frame); the translation start codon (ATG) is indicated by a horizontal arrow. STR denotes a short tandem repeat sequence that has either three or four AAC repeats. Five transcription factor-bindings sites (TFBS) are also indicated. Within this fragment, 69 single nucleotide polymorphisms (SNPs) (bold and underlined) have already been reported in the literature. Those (n = 19) not confirmed in this work are shaded grey. The five novel SNPs are designated as “New” (underlined nucleotides below vertical lines). The SNPs unique to A*3201 are marked by vertical arrows before their respective reference sequence (rs) numbers (from dbSNP database, version 126). In panel b, 53 informative SNPs (minor allele frequency ≥0.02) are linked to 11 HLA alleles found in homozygous state.