Table 4. Individual HLA class I sequence motifs associated with the occurrence of glioblasotma multiforme (GBM) in the Upper Midwest Health Study population (N = 298 subjects) or in the female subset (61 GBM patients and 61 healthy controls).
| HLA motif | In GBM cases | In healthy controls | p | ORc | 95% CIc |
| In all subjects | |||||
| HLA-A, probe 34 | 26 (17.5) | 42 (28.2) | 0.024 | 0.50 | 0.27–0.91 |
| HLA-B, probe 62 | 114 (76.5) | 94 (63.1) | 0.015 | 1.87 | 1.13–3.10 |
| In females only | |||||
| HLA-A, probe 42 | 24 (39.3) | 37 (60.7) | 0.017 | 0.35 | 0.15–0.83 |
| HLA-B, probe 30 | 21 (34.4) | 9 (14.8) | 0.024 | 2.71 | 1.14–6.46 |
| HLA-B, probe 34 | 21 (34.4) | 9 (14.8) | 0.024 | 2.71 | 1.14–6.46 |
As described in the text, HLA motifs are defined by individual sequence-specific oligonucleotide (SSO) probes, including HLA-B probes 30 and 34 that are in exclusive linkage disequilibrium (r 2 = 1.0). The p values correspond to maximum likelihood estimates. OR = odds ratio, CI = confidence interval.