Table 2.
Cytokine & Cytokine Receptor Haplotype Frequencies by Race Haplotypes Common to Caucasians and African Americans
| % | ||||
|---|---|---|---|---|
| Cytokine | Haplotype | Caucasians | African Americans | χ2 p-valuea |
| Pro-inflammatory Cytokines & Cytokine Receptors | ||||
| rs17561-rs2071374 | ||||
| IL1A | C-A | 40.4 | 53.4 | |
| A-A | 31.8 | 17.5 | ||
| C-C | 27.8 | 29.1 | ||
| Other | 0 | 0 | 0.0003 | |
| rs3136558-rs1143627-rs16944 | ||||
| IL1B | A-A-G | 45.2 | 25.5 | |
| A-G-A | 31.0 | 52.6 | ||
| G-A-G | 22.3 | 10.4 | ||
| G-G-A | 1.3 | 6.1 | ||
| A-G-G | 0.1 | 4.4 | ||
| Other | 0.1 | 1.0 | <0.0001 | |
| rs2069763-rs2069762 | ||||
| IL-2 | C-A | 35.3 | 75.5 | |
| A-A | 32.0 | 14.2 | ||
| C-C | 32.6 | 10.3 | ||
| Other | 0.1 | 0 | <0.0001 | |
| rs1800797-rs1800795 | ||||
| IL6 | G-C | 61.7 | 92.7 | |
| A-G | 37.5 | 7.3 | ||
| Other | 0.8 | 0 | <0.0001 | |
| rs1494555-rs7737000 | ||||
| IL7R | A-G | 59.0 | 76.9 | |
| G-G | 29.2 | 17.2 | ||
| A-A | 11.8 | 5.9 | ||
| Other | 0 | 0 | <0.0001 | |
| rs4073-rs2227306 | ||||
| IL8 | A-G | 56.7 | 19.6 | |
| T-A | 39.2 | 14.1 | ||
| T-G | 4.1 | 66.3 | ||
| Other | 0 | 0 | <0.0001 | |
| rs2245414-rs2857261-rs1057972-rs10833 | ||||
| IL15 | G-G-A-G | 44.9 | 47.0 | |
| A-A-T-A | 20.5 | 4.3 | ||
| G-A-T-A | 14.9 | 8.6 | ||
| G-A-T-G | 11.5 | 15.9 | ||
| A-A-T-G | 7.2 | 4.7 | ||
| G-A-A-G | 0.3 | 9.7 | ||
| A-A-A-G | 0.2 | 8.3 | ||
| Other | 0.5 | 1.5 | <0.0001 | |
| rs2296135-rs2228059-rs3136614 | ||||
| IL15RA | C-C-A | 42.7 | 70.5 | |
| A-A-A | 33.0 | 13.4 | ||
| A-A-G | 14.0 | 4.9 | ||
| C-A-G | 4.8 | 3.6 | ||
| C-C-G | 3.5 | 2.2 | ||
| A-C-A | 1.9 | 1.7 | ||
| C-A-A | 0 | 2.4 | ||
| A-C-G | 0.1 | 1.3 | ||
| Other | 0 | 0 | <0.0001 | |
| rs3153-rs7279064 | ||||
| IFNAR2 | G-A | 67.7 | 81.0 | |
| A-C | 29.6 | 13.6 | ||
| G-C | 2.8 | 5.4 | ||
| Other | 0 | 0 | <0.0001 | |
| rs1799964-rs1800630-rs1800629 | ||||
| TNF | A-C-G | 64.2 | 71.8 | |
| A-C-A | 17.3 | 14.6 | ||
| G-A-G | 13.0 | 9.2 | ||
| G-C-G | 5.4 | 4.4 | ||
| Other | 0.1 | 0 | 0.72 | |
| rs1800692-rs887477 | ||||
| TNFRSF1A | G-C | 52.2 | 77.2 | |
| A-A | 39.6 | 9.7 | ||
| G-A | 7.9 | 13.1 | ||
| Other | 0.3 | 0 | <0.0001 | |
| rs2235126-rs4871857 | ||||
| TNFRSF10A | G-G | 50.0 | 63.3 | |
| A-C | 24.7 | 19.1 | ||
| G-C | 22.9 | 15.4 | ||
| A-G | 2.4 | 2.3 | ||
| Other | 0 | 0 | 0.0077 | |
| Anti-inflammatory Cytokines & Cytokine Receptors | ||||
| rs419598-rs454078-rs380092 | ||||
| IL1RN | A-T-A | 33.8 | 72.1 | |
| A-T-T | 39.2 | 21.1 | ||
| G-A-T | 25.6 | 5.8 | ||
| G-A-A | 1.1 | 0 | ||
| Other | 0.3 | 1.0 | <0.0001 | |
| rs2243248-rs2243250 | ||||
| IL4 | A-G | 79.4 | 23.0 | |
| A-A | 13.6 | 62.9 | ||
| C-G | 7.0 | 9.5 | ||
| C-A | 0 | 4.6 | ||
| Other | 0 | 0 | <0.0001 | |
| rs2243268-rs2243290 | ||||
| IL4-IL4R | A-C | 86.7 | 63.6 | |
| C-A | 13.0 | 27.1 | ||
| A-A | 0.3 | 9.3 | ||
| Other | 0 | 0 | <0.0001 | |
| rs2057768-rs1805015-rs8832 | ||||
| IL4R | G-A-G | 43.4 | 12.4 | |
| A-A-A | 22.5 | 23.9 | ||
| G-A-A | 12.5 | 22.7 | ||
| G-G-A | 7.7 | 27.6 | ||
| G-G-G | 7.6 | 7.0 | ||
| A-A-G | 4.8 | 2.2 | ||
| A-G-A | 0.6 | 3.2 | ||
| Other | 0.9 | 1.0 | <0.0001 | |
| rs1805012-rs1805015-rs1801275-rs1805016 | ||||
| IL4R | A-A-A-A | 77.7 | 32.1 | |
| G-G-G-A | 11.4 | 11.3 | ||
| A-A-G-A | 5.2 | 8.2 | ||
| A-G-G-C | 4.3 | 4.9 | ||
| A-A-G-C | 0.4 | 20.2 | ||
| A-G-G-A | 0.1 | 21.4 | ||
| A-G-A-A | 0 | 1.2 | ||
| Other | 0.9 | 0.7 | <0.0001 | |
| rs1800871-rs1800896-rs1800890 | ||||
| IL10 | G-G-A | 37.6 | 14.6 | |
| G-A-T | 30.0 | 24.5 | ||
| A-A-T | 22.6 | 44.0 | ||
| G-G-T | 9.8 | 13.1 | ||
| G-A-A | 0 | 3.8 | ||
| Other | 0 | 0 | <0.0001 | |
| rs1295686-rs20541 | ||||
| IL13 | G-G | 78.3 | 32.0 | |
| A-A | 21.0 | 23.3 | ||
| A-G | 0.6 | 44.7 | ||
| Other | 0 | 0 | <0.0001 | |
| rs928180-rs334358-rs868 | ||||
| TGFβR1 | A-C-A | 68.9 | 76.6 | |
| A-A-G | 21.8 | 16.0 | ||
| G-C-A | 9.3 | 4.4 | ||
| A-A-A | 0 | 2.1 | ||
| Other | 0 | 0.9 | 0.0017 | |
a
p-values adjusted by the Benjamini & Hochberg FDR method.