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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Biochemistry. 2005 Dec 20;44(50):16574–16583. doi: 10.1021/bi0518186

Figure 3. Antibiotic activities of CHIR-090 and L-161,240 compared to tobramycin and ciprofloxacin.

Figure 3

Disc diffusion tests were used to evaluate antibacterial activity. Wild-type E. coli (R477), the LpxC inhibitor hypersensitive E. coli R477 (LpxC G17S), and wild-type P. aeruginosa (PAO1) were tested for killing by L-161,240, CHIR-090, tobramycin, and ciprofloxacin. Each disc contained 20 μg of compound dissolved in DMSO.