Table 1.

LpxC inhibition and/or antibacterial activity of selected compounds.

Compound	% inhibition EcLpxC	% inhibition AaLpxC	G17S mm killing c	R477 mm killing c	PAO1 mm killing c	Time Dependent d
L-161,240 a	96	3	30	19	< 6	no
TU-514 a	50	> 99	< 6	< 6	< 6	no
CHIR-090 b	98	98	38	36	34	yes
tobramycin	Not tested	Not tested	28	26	24	N/A
ciprofloxacin	Not tested	Not tested	37	35	40	N/A

^aTested at 1 μg/mL in the assay at pH 7.4

^bTested at 0.5 μg/mL (1.15 μM) in the assay at pH 7.4

^cTested at 20 μg/disc (disc diameter = 6 mm)

^dTested by preincubation of AaLpxC (3.3 nM) with 0.02 μg/mL inhibitor