Table 2.

Effect of SSRIs/SNRIs and gabapentin on CYP2D6 activity (taken from www.drug-interactions.com) and on hot flashes.

Strong CYP2D6 Inhibitors		Efficacy vs placebo for hot flashes	References
Fluoxetine	Prozac®, Sarafem®	50% vs 36%, p=0.02	(18, 30)
Paroxetine	Paxil®, Pexeva®	62% vs 37%, p=0.007	(12, 20, 30)
Moderate CYP2D6 Inhibitors
Duloxetine	Cymbalta®	Not assessed in placebo-controlled trial	(33)
Medications That Inhibit CYP2D6 Weakly or Not at All
Citalopram	Celexa®	49% vs 23%, p=0.0021	(15, 30)
Escitalopram	Lexapro®	Not assessed in placebo-controlled trial	(34)
Fluvoxamine	Luvox®	Not assessed in placebo-controlled trial	(35)
Gabapentin	Neurontin®	46% vs 15%, p=0.007	(17)
Sertraline	Zoloft®	36% vs 27%, p=0.03	(19, 30)
Venlafaxine	Effexor®	60% vs 27%, p<0.0001	(11, 22, 29)