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(A) Sequence alignment of amino acids 340-360 of TDP-43 from diverse vertebrate species. Mutation sites are bold.
(B) Effects of TARDBP mutation G348C and N352S on protein structure and function predicted using PolyPhen software program and on phosphorylation site prediction using NetPhos 2.0 program. *The lower the score, the more benign the substitution. ** The higher the score, the higher the probability for phosphorylation. Phopshorylation sites for predicted scores are bold.
