Table 5.

Short-term Effects of ECT on Cognitive Measures, According to Treatment Group.^*

	Ultrabrief Right Unilateral ECT	Ultrabrief Bilateral ECT	Brief Pulse Right Unilateral ECT	Brief Pulse Bilateral ECT	PW	EP	EPxPW	No. of Treatments	Age	Baseline Score
Global Cognitive Status: Modified Mini-Mental State Exam
Post-Six ECT	+0.0±1.1a	−0.1±0.9a	−1.3±1.9b	−1.0±1.7b	24.4¶	0.2	0.8	—	2.1	55.9¶
Post-Treatment Course‖	+0.2±1.0a	−0.2±1.0b	−0.6±1.2b	−0.6±1.1b	13.2§	1.8	2.2	0.0	5.3†	47.1¶
Anterograde Memory: Delayed Reproduction Complex Figure Test
Post-Six ECT	−0.1±0.9a	−0.1±0.9a	−0.3±0.8a,b	−0.5±0.6b	4.3†	0.1	0.4	—	0.5	30.2¶
Post-Treatment Course‖	+0.2±1.0a	+0.1±0.8a	−0.3±0.9b	−0.4±0.7b	11.4§	0.4	0.1	3.4	0.1	40.5¶
Anterograde Memory: Delayed Recall Buschke Selective Reminding Test
Post-Six ECT	+0.4±1.1a	+0.3±0.9a	−0.4±1.0b	−0.3±0.7b	18.3¶	0.2	0.4	—	1.9	37.2¶
Post-Treatment Course‖	+0.3±1.0a	+0.2±0.9a,b	−0.2±1.2b	−0.1±0.7b	5.6†	0.3	0.1	0.4	0.3	33.3¶
Anterograde Memory: Randt Story Recall at 24 Hr Delay
Post-Six ECT	−0.2±0.9	−0.3±1.2	−0.9±0.7	−0.7±1.1	4.5†	0.3	0.3	—	0.7	11.4§
Post-Treatment Course	+0.1±1.1a	−0.2±1.2a,b	−0.6±0.8a,b	−0.7±1.2b	4.7†	0.4	0.1	1.7	0.0	12.4§
Retrograde Memory: Autobiographical Memory Interview
Post-Treatment Course‖	0.0±1.0a	−0.4±1.1b	−1.0±1.0c	−1.4±1.0d	44.7¶	10.0‡	0.0	31.6¶	1.7	81.9¶
Retrograde Memory: Goldberg Public Events
Post-Treatment Course‖	0.0±1.2a	−0.2±0.9a	−0.2±1.2a	−0.6±1.0b	9.8‡	9.4‡	1.5	2.7	0.1	264.4¶
Subjective Cognitive Evaluation
Global Memory Assessment‖	−0.3±1.0a	−1.1±0.9b	−1.4±1.0b	−1.4±1.0b	15.8§	7.5‡	0.7	8.6‡	10.0‡	—

^*Plus–minus values are means±SD. PW is the F-value for the main effect of pulse width from the ANCOVA. EP is F-value for the main effect of electrode placement. EPxPW is the F-value for the interaction between pulse width and electrode placement. No. of Treatments is the F-value for the covariate, number of ECT treatments. Age is the F-value for the covariate, patient age. For all measures lower values indicate greater impairment. Values with different letter superscripts differed significantly from each other in post hoc t-tests on least-squares adjusted means (P<0.05).

^†F-value was significant in the ANCOVA (P<0.05)

^‡F-value was significant in the ANCOVA (P<0.01)

^§F-value was significant in the ANCOVA (P<0.001)

^¶F-value was significant in the ANCOVA (P<0.0001).

^‖Declared a priori as a primary outcome measure.