Table 3.
Prediagnostic antibodies to JC virus (JCV) and colorectal cancer, Washington County, MD, 1975–2006
| Matched analysis1 |
Multivariable model2 |
|||||||
|---|---|---|---|---|---|---|---|---|
| cases |
controls |
|||||||
| JCV serostatus | n | % | n | % | odds ratio | 95% CI | odds ratio | 95% CI |
| Overall: | ||||||||
| JCV-negative | 202 | 27.7 | 185 | 25.4 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 527 | 72.3 | 544 | 74.6 | 0.90 | (0.79–1.03) | 0.94 | (0.72–1.21) |
| By sex: | ||||||||
| males | ||||||||
| JCV-negative | 84 | 26.3 | 84 | 26.3 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 235 | 73.7 | 235 | 73.7 | 1.00 | (0.81–1.24) | 0.89 | (0.59–1.34) |
| females | ||||||||
| JCV-negative | 118 | 28.8 | 101 | 24.6 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 292 | 71.2 | 309 | 75.4 | 0.84 | (0.71–0.99) | 0.96 | (0.68–1.35) |
| By disease site: | ||||||||
| colon cancer | ||||||||
| JCV-negative | 149 | 27.8 | 142 | 26.5 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 387 | 72.2 | 394 | 73.5 | 0.94 | (0.81–1.10) | 1.00 | (0.74–1.34) |
| distal colon3 | ||||||||
| JCV-negative | 59 | 29.2 | 49 | 24.3 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 143 | 70.8 | 153 | 75.7 | 0.81 | (0.64–1.02) | 0.66 | (0.39–1.11) |
| proximal colon4 | ||||||||
| JCV-negative | 76 | 25.8 | 85 | 28.8 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 219 | 74.2 | 210 | 71.2 | 1.15 | (0.94–1.41) | 1.43 | (0.96–2.12) |
| rectal cancer | ||||||||
| JCV-negative | 53 | 27.5 | 43 | 22.3 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 140 | 72.5 | 150 | 77.7 | 0.77 | (0.58–1.03) | 0.69 | (0.38–1.27) |
| By stage at diagnosis: | ||||||||
| Local | ||||||||
| JCV-negative | 114 | 30.2 | 115 | 30.5 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 263 | 69.8 | 262 | 69.5 | 1.01 | (0.88–1.16) | 1.10 | (0.80–1.52) |
| Regional | ||||||||
| JCV-negative | 52 | 28.4 | 40 | 21.9 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 131 | 71.6 | 143 | 78.1 | 0.75 | (0.59–0.97) | 0.66 | (0.39–1.13) |
| Distant | ||||||||
| JCV-negative | 25 | 22.7 | 24 | 21.8 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 85 | 77.3 | 86 | 78.2 | 0.96 | (0.69–1.33) | 0.68 | (0.23–2.02) |
| By time between blood draw and diagnosis5: | ||||||||
| <1–9 years | ||||||||
| JCV-negative | 94 | 34.4 | 82 | 30.0 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 179 | 65.6 | 191 | 70.0 | 0.79 | (0.61–1.03) | 0.77 | (0.55–1.08) |
| 10–19 years | ||||||||
| JCV-negative | 85 | 29.6 | 89 | 31.0 | 1.00 | reference | 1.00 | reference |
| JCV-positive | 202 | 70.4 | 198 | 69.0 | 1.11 | (0.81–1.53) | 1.32 | (0.85–2.06) |
| 20–31 years | ||||||||
| JCV-negative | 23 | 13.6 | 15 | 8.9 | 1.00 | reference | - | - |
| JCV-positive | 146 | 86.4 | 154 | 91.1 | 0.60 | (0.36–1.01) | - | - |
1
Cases and controls matched on age, sex, race, cohort, and date of blood draw
2
Results presented for CLUE II participants only; conditional logistic regression model included baseline smoking status and body mass index
3
Distal includes the descending and sigmoid colon
4
Proximal includes the cecum, ascending colon, hepatic flexure, transverse colon, and splenic flexure
5
118 case-control pairs who participated in both CLUE cohorts contributed observations to two different strata for the simple models; only their CLUE II observations were included in the multivariable model