Table 5.

Prediagnostic antibodies to JC virus (JCV) and colorectal adenomas by gender, Washington County, MD, 1989–2006

	males								females
	cases		controls						cases		controls
JCV serostatus	n	%	n	%	OR1	95% CI1	OR2	95% CI2	n	%	n	%	OR1	95% CI1	OR2	95% CI2
JCV-negative	20	32.8	30	49.2	1.00	reference	1.00	reference	45	72.6	30	48.4	1.00	reference	1.00	reference
JCV-positive	41	67.2	31	50.8	2.25	(1.20–4.23)	2.31	(1.20–4.46)	17	27.4	32	51.6	0.32	(0.16–0.63)	0.31	(0.14–0.67)
By number of adenomas:
One adenoma
JCV-negative	11	39.3	12	42.9	1.00	reference	1.00	reference	27	75.0	16	44.4	1.00	reference	1.00	reference
JCV-positive	17	60.7	16	57.1	1.17	(0.54–2.53)	1.37	(0.48–3.88)	9	25.0	20	55.6	0.27	(0.11–0.66)	0.11	(0.03–0.40)
Multiple adenomas
JCV-negative	9	27.3	18	54.6	1.00	reference	1.00	reference	18	69.2	14	53.9	1.00	reference	1.00	reference
JCV-positive	24	72.7	15	45.5	5.50	(1.51–20.08)	6.71	(1.34–33.60)	8	30.8	12	46.2	0.43	(0.15–1.20)	0.40	(0.09–1.90)
By size:
<0.55cm
JCV-negative	10	47.6	9	42.9	1.00	reference	1.00	reference	19	70.4	12	44.4	1.00	reference	1.00	reference
JCV-positive	11	52.4	12	57.1	0.75	(0.26–2.19)	0.58	(0.20–1.67)	8	29.6	15	55.6	0.30	(0.11–0.85)	0.30	(0.12–0.74)
>=0.55cm
JCV-negative	6	22.2	15	55.6	1.00	reference	1.00	reference	17	81.0	14	66.7	1.00	reference	1.00	reference
JCV-positive	21	77.8	12	44.4	4.00	(1.41–11.35)	3.83	(1.20–12.25)	4	19.1	7	33.3	0.50	(0.18–1.41)	0.56	(0.20–1.56)
By site:
Rectum
JCV-negative	3	20.0	6	40.0	1.00	reference	1.00	reference	9	81.8	3	27.3	1.00	reference	1.00	reference
JCV-positive	12	80.0	9	60.0	2.50	(0.71–8.83)	2.69	(0.87–8.27)	2	18.2	8	72.7	0.12	(0.00–0.85)	NE5	NE5
Distal3
JCV-negative	13	37.1	19	54.3	1.00	reference	1.00	reference	25	73.5	18	52.9	1.00	reference	1.00	reference
JCV-positive	22	62.9	16	45.7	2.50	(1.03–6.10)	2.38	(0.89–6.38)	9	26.5	16	47.1	0.36	(0.15–0.89)	0.31	(0.11–0.87)
Proximal4
JCV-negative	7	26.9	13	50.0	1.00	reference	1.00	reference	20	71.4	16	57.1	1.00	reference	1.00	reference
JCV-positive	19	73.1	13	50.0	4.00	(1.12–14.35)	5.31	(0.87–32.27)	8	28.6	12	42.9	0.50	(0.20–1.22)	0.45	(0.15–1.35)
By Histology:
Tubular
JCV-negative	11	30.6	16	44.4	1.00	reference	1.00	reference	29	78.4	18	48.7	1.00	reference	1.00	reference
JCV-positive	25	69.4	20	55.6	2.25	(0.92–5.49)	1.97	(0.83–4.69)	8	21.6	19	51.4	0.21	(0.08–0.61)	0.19	(0.06–0.56)
Tubulovillous & Villous
JCV-negative	9	36.0	14	56.0	1.00	reference	1.00	reference	15	65.2	10	43.5	1.00	reference	1.00	reference
JCV-positive	16	64.0	11	44.0	2.25	(0.92–5.49)	2.90	(0.75–11.21)	8	34.8	13	55.5	0.38	(0.13–1.05)	0.33	(0.07–1.65)

¹Cases and controls matched on age, sex, race, cohort, date of blood draw

²Cases and controls matched on age, sex, race, cohort, date of blood draw; conditional logistic regression model included baseline smoking status (current/former/never) and body mass index

³Distal includes the descending and sigmoid colon

⁴Proximal includes the cecum, ascending colon, hepatic flexure, transverse colon, and splenic flexure

⁵Not estimable