Table 2.

Comparison of patients with infantile neuronal lipofuscinosis (INCL) versus controls undergoing anesthesia for diagnostic procedures

Variable	INCL	Controls	P value
Data from first anesthetic for each patient
Number of patients	8	25
Male (%)	4 (50)	11 (44)	1.00
Female (%)	4 (50)	14 (56)
Age (months) *	25±6.6	44±19.8	<0.001
Range	10.5-32	18-92
Baseline temperature (°C) *	36.2±0.4	36.8±0.4	<0.001
Data from all anesthetics in all patients
Number of anesthetics	31	31
Age (months) †	39±5.6	46±3.7	0.34
Duration of anesthesia (minutes) †‡	280±10.3	231±8.2	0.002
Baseline temperature (°C) †	36.4±0.1	36.8±0.1	0.007
Number of anesthetics when hypothermia was observed (%) §	18 (29%)	0 (0%)	<0.001
Lowest temperature (°C) * ‖	34.3±1.4	36.6±0.6
Range	32-36.7	35.9-38.0
Change in temperature from baseline (°C) †	-1.2±0.2	-0.2±0.1	<0.001
Baseline heart rate †	100±4	108±3	0.134
Number of anesthetics when bradycardia was recorded §	10 (16%)	1 (2%)	<0.001
Slowest heart rate * ‖	73±13.3	103±19.1
Range	60-100	73-160
Time to first occurrence of lowest temperature (minutes) †	192±17.2	149±16.2	0.08
Time in PACU (minutes) †	67±6.9	56±6.7	0.25

^*Variables are shown as Mean± SD (standard deviation).

^†Least square means and associated standard error, from repeated measures analyses.

^‡Duration of anesthesia reflects time from induction of to emergence from general anesthesia.

^§Exact procedure for binomial clustered data.

^‖Lowest temperatures and heart rates were not compared because there were large differences between groups in the sample sizes. PACU= postanesthesia care unit