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The C-terminus of PC-TP is the membrane binding domain. A) The α4 helix of the C-terminus of PC-TP can be subdivided into two functionally distinct types, a membrane spanning helix (α4a) and an amphipathic helix (α4b). B) A model of PC-TP-membrane binding that occurs when α4b aligns at the surface of a bilayer. Extraction of a phosphatidylcholine may be accomplished when α4a penetrates into the membrane.
