Figure 2.

Activity-dependent changes in spike peak voltage. A, Peak voltage and instantaneous spike frequency as a function of time over the course of a burst. Data are from 100 bursts in a single experiment. Single data points are superimposed with mean values sorted by spike index (±SD in x and y). spk, Spike. B, Peak voltage plotted as a function of instantaneous spike frequency, from the same data as in A. Mean values show slight differences for the first (right arrow) and second (left arrow) halves of the burst. C, Across experiments, the maximum difference in spike peak voltage was not dependent on the interburst membrane potential (Vm). D, Across experiments, the maximum difference in spike peak voltage was dependent on the maximum instantaneous spike frequency. IF, Instantaneous spike frequency; adj., adjusted; max, maximum.