Table 2.

Genes differentially expressed in response to lithium^a.

Probe set ID	Gene	Microarray				RT-PCR	Description
		Normalized Signal intensity (log2) b		Fold Change	p-value	Fold Changec
		− LiCl	+ LiCl
Down-regulated gene
1631512_at	CG9377	7.17 ± 0.09	6.05 ± 0.10	−2.17	1.54E−04	−1.30 ± 0.06	Serine type endopeptidase
Up-regulated genes
1630258_at	Glutathione S transferase D2	6.27 ± 0.21	7.40 ± 0.30	2.19	6.17E−03	1.39 ± 0.14	Glutathione S transferase
1639180_at 1639694_s_at	Arc1	10.01 ± 0.08 8.83 ± 0.06	11.19 ± 0.35 10.00 ± 0.32	2.27 2.25	4.80E−03 3.45E−03	2.18 ± 0.43	zinc ion binding; nucleic acid binding
1623770_at	CG1673	7.10 ± 0.09	8.30 ± 0.04	2.31	2.60E−05	1.30 ± 0.10	Branched chain amino acid transaminase
1640775_a_at	NAD dependent methylenetetrahydrof olate dehydrogenase	8.49 ± 0.11	9.86 ± 0.37	2.59	3.62E−03	1.68 ± 0.12	methenyltetrahydrofolate cyclohydrolase/dehydrogenase/dehydrogenase
1626144_at	CG7763	5.61 ± 0.54	7.20 ± 0.25	3.02	9.42E−03	3.28 ± 0.35	C type lectin/sugar binding
1640884_at	CG15784	9.16 ± 0.02	10.84 ± 0.57	3.22	7.06E−03	1.84 ± 0.02	unknown
1626324_at	Cyp309a1	7.69 ± 0.28	9.39 ± 0.37	3.25	3.22E−03	2.36 ± 0.28	monooxygenase
1636594_at		7.31 ± 0.07	9.28 ± 0.07	3.91	4.91E−06		Sodium:neurotransmitter
1632986_a_at	CG15088	6.75 ± 0.09	9.26 ± 0.02	5.68	1.12E−06	3.74 ± 0.49	symporter
1626429_at	Larval serum protein 1 γ	4.50 ± 0.17	6.69 ± 0.22	4.55	1.71E−04	2.41 ± 0.16	oxygen transporter
1632565_at	Bicoid interacting protein 1	7.64 ± 0.03	10.06 ± 0.73	5.32	4.73E−03	3.61 ± 0.18	transcription co repressor
1638182_at	CG5999	6.79 ± 0.32	10.46 ± 1.11	12.7	5.32E−03	5.12 ± 0.96	UDP glucuronosyltransferase

^aGenes were selected based on the following criteria: 2.0 fold or greater changes in the normalized signal intensities with p-value with 0.01 or less in Student’s t-test.

^bSignal intensities of each chip were normalized values using RMA algorithm and presented in log2.

^cFold change values estimated from RT-PCR analyses were shown as Ave ± SEM, n=4.