Table 3.
Functional annotation chart of the selected lithium-responsive genes analyzed by DAVID.
| Term | p-valuea | Fold Enrichmentb | |
|---|---|---|---|
| 1 | branched chain family amino acid metabolic process (GO:0009081) | 7.57E−04 | 69.1 |
| 2 | stress response (SP PIR keywords) | 9.23E−05 | 43.8 |
| 3 | valine, leucine and isoleucine degradation (KEGG pathway: dme00280) | 1.69E−05 | 15.9 |
| 4 | organic acid metabolic processc (GO:0006082) | 8.20E−06 | 5.99 |
| 5 | carboxylic acid metabolic processc (GO:0019752) | 8.20E−06 | 5.99 |
| 6 | oxidoreductase (SP PIR keywords) | 3.18E−05 | 5.83 |
| 7 | mitochondrion (GO:0005739) | 9.09E−05 | 4.29 |
| 8 | amino acid metabolic process (GO:0006520) | 8.05E−04 | 6.11 |
| 9 | oxidoreductase activity (GO:0016491) | 9.69E−04 | 3.16 |
| 10 | hydrolase (SP PIR keywords) | 4.03E−04 | 3.15 |
| 11 | cytoplasmic part (GO:0044444) | 1.66E−04 | 2.25 |
| 12 | cytoplasm (GO:0005737) | 8.09E−04 | 1.92 |
| 13 | catalytic activity (GO:0003824) | 3.48E−05 | 1.71 |
a
Modified Fisher Exact p-value (EASE score),
b
Enrichment factor for the lithium responsive genes (fold change >1.2; FDR<0.05),
c
The identical genes are assigned to these terms for Drosophila genome.