Table 2.
Vaccine-induced protection in mice following i.d. immunization and aerosol infection with M. tuberculosis.
| Vaccine groupsa | CFUb Log10 | S.D. | Log10 Protection vs. Saline | P Valuec |
|---|---|---|---|---|
| Saline | 6.14 | 0.22 | NA | NA |
| BCG | 5.14 | 0.38 | 1.00 | <0.01 |
| ID83 | 5.90 | 0.28 | 0.24 | >0.05 |
| ID83+TLR4-EM | 5.69 | 0.28 | 0.45 | <0.01 |
| ID83+TLR7-EM | 5.79 | 0.16 | 0.35 | <0.01 |
| ID83+TLR9-EM | 5.54 | 0.25 | 0.60 | <0.01 |
| ID83+TLR4/7-EM | 5.59 | 0.20 | 0.56 | <0.01 |
| ID83+TLR4/9-EM | 5.61 | 0.22 | 0.54 | <0.01 |
| ID83+TLR7/9-EM | 5.67 | 0.19 | 0.47 | <0.01 |
a
Mice were immunized by the i.d. route three times, 3 wk apart.
b
Viable colony forming units (CFU) of bacteria in the lungs of immunized mice compared to saline controls 4 wk after a low-dose aerosol challenge with M. tuberculosis H37Rv. Data represents the mean of two independent experiments (n=14 mice total).
c
One way ANOVA followed by Dunnett’s Multiple Comparison Test was used for statistical analysis. P values <0.05 are considered statistically significant.