Table II.
Trends of ESAT-6, CFP-10, ESAT-6/CFP-10 and SKSD-specific IFN-γ-secreting T cells during follow up
| Geometric mean counts of spot forming cells (95% CI), n | Test for trend | Geometric mean counts of spot forming cells (95% CI), n | Test for trend | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 months | 3 months | 6 months | 0 to 6 months | 12 months | 18 months | 28 months | 0 to 28 months | |||||||
| ESAT-6 | ||||||||||||||
| IFN-γ | 24 (6 to 98) | 23 | 11 (3 to 44) | 22 | 21 (6 to 81) | 22 | P=0.77 | 8 (2 to 40) | 16 | 8 (2 to 40) | 17 | 27 (5 to 145) | 12 | P=0.04 |
| IL-2 | 2 (0 to 9) | 10 | 5 (2 to 20) | 19 | 11 (3 to 37) | 21 | P=0.06 | 4 (1 to 14) | 16 | 5 (1 to 20) | 17 | 12 (2 to 81) | 12 | P=0.83 |
| CFP-10 | ||||||||||||||
| IFN-γ | 60 (18 to 208) | 23 | 70 (21 to 227) | 22 | 76 (26 to 220) | 22 | P=0.75 | 1 (1 to 1) | 16 | 18 (4 to 85) | 17 | 18 (2 to 149) | 12 | P=0.002 |
| IL-2 | 5 (1 to 53) | 10 | 11 (3 to 43) | 19 | 30 (12 to 75) | 21 | P=0.06 | 6 (2 to 27) | 16 | 5 (1 to 20) | 17 | 11 (1 to 92) | 12 | P=0.41 |
| ESAT-6/CFP-10 | ||||||||||||||
| IFN-γ | 111 (32 to 384) | 23 | 119 (38 to 370) | 22 | 161 (60 to 430) | 22 | P=0.57 | 44 (9 to 206) | 16 | 36 (7 to 178) | 17 | 57 (8 to 399) | 12 | P=0.005 |
| IL-2 | 5 (1 to 58) | 10 | 22 (6 to 86) | 19 | 55 (23 to 134) | 21 | P=0.02 | 14 (3 to 60) | 16 | 9 (2 to 44) | 17 | 31 (4 to 237) | 12 | P=0.72 |
| SKSD | ||||||||||||||
| IFN-γ | 19 (8 to 44) | 21 | 22 (12 to 41) | 22 | 25 (12 to 51) | 22 | P=0.26 | 28 (10 to 81) | 16 | 23 (10 to 51) | 17 | 19 (7 to 54) | 12 | P=0.73 |
| IL-2 | 89 (0 to 8250569) | 2 | 24 (12 to 46) | 17 | 28 (13 to 61) | 18 | P=0.85 | 34 (14 to 85) | 14 | 35 (14 to 89) | 13 | 49 (25 to 95) | 12 | P=0.29 |