No. of surviving bacteria after an opsonophagocytosis assay at various dilutions of serum pools from postimmune adults (A), preimmune children (B), and postimmune children (C). Target bacteria included serotypes 6A (solid red lines), 6B (dashed blue lines), and 6C (dotted black lines). Filled symbols indicate 6A and 6C strains obtained from Massachusetts during this study, and open symbols indicate strains used in another study [13]. The 6A strains used were LE4007 (red filled squares), FRV004H (red filled diamonds), 164S (red filled triangles), OREP6A (red open squares), and TriRep6A (red open diamonds) ; 6B strains were STREP6B (blue open squares) and SPEC6B (blue open diamonds) ; and 6C strains were CH2006 (black filled squares), ND6012 (black filled diamonds), 3041 (black filled triangles), FRV052H (black filled circles), 462–3–6 (black inverted triangles), CHPA037 (black open squares), KK177 (black open diamonds), and St745/04 (black open triangles).