Table 1.
Cell Cycle Genes
| Number of SNPs | |||||||
|---|---|---|---|---|---|---|---|
| Gene | Chr. | Start (bp) | Size (kb) | MAY+NCO† | SEA+MAL+STA‡ | CEU§ | NIEHS SNPs|| |
| CDKN2C | 1 | 51,206,196 | 6.7 | 1 | 2 | 7 | 19 |
| CDKN1A | 6 | 36,754,465 | 8.6 | 4 | 11 | 40 | 42 |
| CCND3 | 6 | 42,010,649 | 113.8 | 7 | 6 | 87 | 32 |
| CDKN2A-CDKN2B | 9 | 21,957,751 | 41.6 | 9 | 17 | 76 | 96 |
| CCND1 | 11 | 69,165,054 | 13.4 | 5 | 7 | 16 | 53 |
| CCND2 | 12 | 4,253,199 | 31.6 | 4 | 14 | 83 | 102 |
| CDKN1B | 12 | 12,761,576 | 5.0 | 8 | 8 | 17 | 15 |
| CDK2 | 12 | 54,646,826 | 6.0 | 7 | 2 | 23 | 24 |
| CDK4 | 12 | 56,428,270 | 4.1 | 3 | 2 | 11 | 26 |
| RB1 | 13 | 47,775,884 | 178.1 | 8 | 11 | 171 | 197 |
| CDKN2D | 19 | 10,538,138 | 2.5 | 2 | 2 | 15 | 5 |
| CCNE1 | 19 | 34,994,741 | 12.3 | 2 | 4 | 19 | 48 |
|
|
|||||||
| 60 | 86 | 565 | 659 | ||||
†
Source for tagging SNPs was HapMap release 20.
‡
Source for tagging SNPs was NIEHS SNPs, except CCND2 and CDKN1B which used HapMap and CDKN2C which used both HapMap and NIEHS SNPs (October 2005); CCND3 rs1051130 excluded due to HWE p < 0.001.
§
HapMap release 21a, within 10 kb of gene start or stop.
||
September 2007.