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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 Mar 3;18(3):935–944. doi: 10.1158/1055-9965.EPI-08-0860

Table 3.

Cell Cycle SNPs and Risk of Ovarian Cancer

OR (95% CI)
Gene SNP Distance (bp) MAY+NCO SEA+MAL+STA Combined Combined Imputed: HapMap+NIEHS Combined Imputed: HapMap Only
CDKN2C rs3176459 N.A. -- 1.00 (0.90 – 1.10) 1.00 (0.90 – 1.10) 0.98 (0.89 – 1.08) 0.98 (0.89 – 1.08)
rs12855 2,846 1.02 (0.80 – 1.30) 1.01 (0.86 – 1.19) 1.01 (0.89 – 1.16) 1.01 (0.88 – 1.15) 1.01 (0.88 – 1.15)
CDKN1A rs1977172 N.A. 1.11 (0.90 – 1.38) -- 1.11 (0.90 – 1.38) 1.12 (0.90 – 1.39) 1.09 (0.91 – 1.31)
rs3829963 2,632 1.19 (0.97 – 1.46) -- 1.19 (0.97 – 1.46) 1.17 (0.96 – 1.42) 1.06 (0.92 – 1.22)
rs733590 817 0.87 (0.75 – 1.02) -- 0.87 (0.75 – 1.02) 0.98 (0.87 – 1.10) 1.00 (0.93 – 1.08)
rs762624 385 -- 1.09 (0.98 – 1.21) 1.09 (0.98 – 1.21) 1.08 (0.97 – 1.20) 1.08 (0.97 – 1.20)
rs2395655 108 -- 1.10 (1.00 – 1.21) 1.10 (1.00 – 1.21) 1.04 (0.95 – 1.13) 1.03 (0.95 – 1.11)
rs3176331 1,829 -- 1.02 (0.89 – 1.18) 1.02 (0.89 – 1.18) 1.00 (0.87 – 1.16) 1.01 (0.88 – 1.17)
rs3176336 1,291 -- 0.97 (0.88 – 1.07) 0.97 (0.88 – 1.07) 0.97 (0.88 – 1.07) 0.97 (0.88 – 1.07)
rs3176343 1,451 -- 1.05 (0.84 – 1.30) 1.05 (0.84 – 1.30) 1.04 (0.84 – 1.29) 1.04 (0.84 – 1.29)
rs1801270 1,704 -- 0.95 (0.78 – 1.15) 0.95 (0.78 – 1.15) 0.93 (0.77 – 1.13) 0.95 (0.79 – 1.15)
rs3176352 368 -- 1.08 (0.97 – 1.20) 1.08 (0.97 – 1.20) 1.08 (0.97 – 1.20) 1.01 (0.92 – 1.11)
rs1059234 1,258 -- 0.96 (0.79 – 1.16) 0.96 (0.79 – 1.16) 0.96 (0.79 – 1.17) 0.96 (0.79 – 1.16)
rs6457937 754 -- 0.92 (0.68 – 1.24) 0.92 (0.68 – 1.24) 0.91 (0.68 – 1.23) 0.91 (0.68 – 1.23)
rs3176359 391 -- 1.61 (0.72 – 3.56) 1.61 (0.72 – 3.56) 1.63 (0.73 – 3.61) 1.63 (0.73 – 3.61)
rs7767246 4,473 0.82 (0.69 – 0.99) 1.11 (0.98 – 1.25) 1.01 (0.92 – 1.12) 1.00 (0.91 – 1.11) 1.02 (0.92 – 1.12)
CCND3 rs2479726 N.A. 0.92 (0.79 – 1.08) -- 0.92 (0.79 – 1.08) 0.93 (0.80 – 1.09) 0.93 (0.80 – 1.09)
rs3828855 2,310 0.98 (0.76 – 1.25) -- 0.98 (0.76 – 1.25) 0.97 (0.76 – 1.25) 0.97 (0.76 – 1.25)
rs3218114 1,946 -- 0.98 (0.86 – 1.10) 0.98 (0.86 – 1.10) 0.97 (0.86 – 1.10) 0.97 (0.86 – 1.10)
rs3218110 157 -- 1.09 (0.98 – 1.22) 1.09 (0.98 – 1.22) 1.08 (0.97 – 1.21) 1.08 (0.97 – 1.21)
rs3218108 146 0.93 (0.79 – 1.09) -- 0.93 (0.79 – 1.09) 0.93 (0.79 – 1.10) 0.93 (0.79 – 1.10)
rs9529 352 0.91 (0.78 – 1.07) 0.93 (0.84 – 1.03) 0.93 (0.85 – 1.01) 0.93 (0.85 – 1.01) 0.93 (0.85 – 1.01)
rs2479717 2,167 -- 1.00 (0.90 – 1.12) 1.00 (0.90 – 1.12) 1.02 (0.92 – 1.13) 1.02 (0.92 – 1.13)
rs3218092 1,487 -- 0.98 (0.87 – 1.11) 0.98 (0.87 – 1.11) 0.97 (0.86 – 1.10) 0.97 (0.86 – 1.10)
rs1410492 1,194 -- 1.06 (0.95 – 1.18) 1.06 (0.95 – 1.18) 1.06 (0.95 – 1.18) 1.06 (0.95 – 1.18)
rs3218086 2,209 1.32 (1.10 – 1.58) -- 1.32 (1.10 – 1.58) 1.31 (1.09 – 1.57) 1.31 (1.09 – 1.57)
rs3218085 115 1.17 (0.63 – 2.17) -- 1.17 (0.63 – 2.17) 1.18 (0.63 – 2.20) 1.18 (0.63 – 2.20)
rs9381100 1,006 0.90 (0.76 – 1.06) -- 0.90 (0.76 – 1.06) 0.89 (0.75 – 1.05) 0.89 (0.75 – 1.05)
CDKN2A-B rs3731257 N.A. -- 0.89 (0.80 – 1.00) 0.89 (0.80 – 1.00) 0.89 (0.80 – 1.00) 0.93 (0.85 – 1.03)
rs3088440 1,938 -- 1.08 (0.91 – 1.28) 1.08 (0.91 – 1.28) 1.00 (0.86 – 1.16) 1.07 (0.91 – 1.26)
rs11515 40 -- 1.07 (0.94 – 1.23) 1.07 (0.94 – 1.23) 1.06 (0.92 – 1.21) 0.98 (0.87 – 1.10)
rs3731249 2,717 0.92 (0.62 – 1.35) 0.89 (0.67 – 1.19) 0.91 (0.72 – 1.14) 0.90 (0.72 – 1.14) 0.90 (0.72 – 1.14)
rs3731239 3,302 -- 1.05 (0.95 – 1.16) 1.05 (0.95 – 1.16) 1.08 (0.99 – 1.18) 1.11 (1.02 – 1.20)
rs2811709 5,933 0.80 (0.64 – 0.99) -- 0.80 (0.64 – 0.99) 0.79 (0.64 – 0.99) 0.96 (0.85 – 1.08)
rs4074785 1,432 -- 1.09 (0.92 – 1.28) 1.09 (0.92 – 1.28) 1.08 (0.92 – 1.28) 1.10 (0.93 – 1.29)
rs3731222 2,331 -- 0.96 (0.83 – 1.10) 0.96 (0.83 – 1.10) 0.96 (0.84 – 1.11) 0.92 (0.82 – 1.04)
rs3731211 2,933 -- 0.98 (0.88 – 1.09) 0.98 (0.88 – 1.09) 0.97 (0.88 – 1.08) 0.92 (0.84 – 1.00)
rs7036656 3,610 0.79 (0.67 – 0.93) -- 0.79 (0.67 – 0.93) 0.79 (0.67 – 0.92) 0.94 (0.86 – 1.02)
rs3731197 914 -- 1.03 (0.93 – 1.13) 1.03 (0.93 – 1.13) 1.02 (0.93 – 1.11) 1.03 (0.93 – 1.13)
rs3218020 6,501 -- 0.99 (0.89 – 1.10) 0.99 (0.89 – 1.10) 0.98 (0.89 – 1.07) 1.00 (0.91 – 1.09)
rs2811712 163 -- 1.05 (0.90 – 1.22) 1.05 (0.90 – 1.22) 1.04 (0.89 – 1.21) 0.95 (0.84 – 1.08)
rs3218012 625 -- 1.00 (0.91 – 1.10) 1.00 (0.91 – 1.10) 0.98 (0.90 – 1.06) 0.98 (0.89 – 1.08)
rs3218009 97 1.19 (0.96 – 1.46) 0.99 (0.86 – 1.14) 1.05 (0.93 – 1.17) 1.04 (0.93 – 1.17) 1.04 (0.93 – 1.17)
rs3218005 1,490 -- 1.06 (0.91 – 1.25) 1.06 (0.91 – 1.25) 1.02 (0.88 – 1.18) 0.95 (0.84 – 1.09)
rs3217992 2,976 -- 0.97 (0.88 – 1.08) 0.97 (0.88 – 1.08) 0.96 (0.87 – 1.05) 0.98 (0.90 – 1.06)
rs1063192 144 1.09 (0.94 – 1.25) 0.98 (0.89 – 1.08) 1.01 (0.94 – 1.10) 1.01 (0.93 – 1.09) 1.02 (0.94 – 1.10)
rs3217986 1,963 -- 1.10 (0.93 – 1.29) 1.10 (0.93 – 1.29) 1.08 (0.92 – 1.27) 1.09 (0.92 – 1.28)
rs2069418 4,368 1.11 (0.97 – 1.28) -- 1.11 (0.97 – 1.28) 1.13 (0.98 – 1.31) 1.13 (0.98 – 1.31)
rs575427 1,779 0.84 (0.66 – 1.07) -- 0.84 (0.66 – 1.07) 0.83 (0.65 – 1.07) 0.91 (0.79 – 1.04)
rs13298881 574 0.94 (0.75 – 1.19) -- 0.94 (0.75 – 1.19) 0.92 (0.73 – 1.17) 1.09 (0.95 – 1.25)
rs10811640 1,360 0.97 (0.84 – 1.12) -- 0.97 (0.84 – 1.12) 0.96 (0.83 – 1.10) 0.99 (0.91 – 1.07)
CCND1 rs602652 N.A. -- 1.11 (1.01 – 1.23) 1.11 (1.01 – 1.23) 1.08 (1.00 – 1.17) 1.14 (1.04 – 1.25)
rs3862792 214 -- 0.79 (0.58 – 1.09) 0.79 (0.58 – 1.09) 0.79 (0.58 – 1.09) 0.79 (0.58 – 1.09)
rs603965 54 1.01 (0.88 – 1.17) 1.12 (1.02 – 1.23) 1.09 (1.00 – 1.17) 1.08 (1.00 – 1.17) 1.08 (1.00 – 1.17)
rs3212879 571 -- 0.91 (0.83 – 1.00) 0.91 (0.83 – 1.00) 0.93 (0.86 – 1.01) 0.90 (0.82 – 0.99)
rs649392 1,312 1.00 (0.87 – 1.14) -- 1.00 (0.87 – 1.14) 0.93 (0.86 – 1.01) 0.92 (0.85 – 1.00)
rs3212891 714 -- 0.90 (0.82 – 1.00) 0.90 (0.82 – 1.00) 0.93 (0.86 – 1.00) 0.90 (0.82 – 0.99)
rs678653 1,230 1.01 (0.87 – 1.17) 0.96 (0.87 – 1.06) 0.97 (0.90 – 1.06) 0.97 (0.90 – 1.06) 0.97 (0.90 – 1.06)
rs7178 2,293 0.83 (0.64 – 1.09) 1.21 (1.02 – 1.45) 1.08 (0.93 – 1.24) 1.07 (0.93 – 1.24) 1.07 (0.93 – 1.24)
rs11603541 3,343 0.90 (0.72 – 1.13) -- 0.90 (0.72 – 1.13) 0.90 (0.72 – 1.14) 0.91 (0.72 – 1.14)
CCND2 rs1049606 N.A. 1.06 (0.92 – 1.22) -- 1.06 (0.92 – 1.22) 1.04 (0.94 – 1.15) 1.08 (0.95 – 1.22)
rs3217795 3,028 -- 0.95 (0.80 – 1.12) 0.95 (0.80 – 1.12) 0.95 (0.80 – 1.12) 0.95 (0.80 – 1.12)
rs3217805 2,020 -- 0.96 (0.87 – 1.06) 0.96 (0.87 – 1.06) 1.01 (0.92 – 1.11) 1.01 (0.92 – 1.11)
rs3217820 2,288 -- 1.03 (0.93 – 1.14) 1.03 (0.93 – 1.14) 0.95 (0.87 – 1.05) 0.95 (0.87 – 1.05)
rs3217852 7,394 -- 0.97 (0.87 – 1.09) 0.97 (0.87 – 1.09) 0.98 (0.88 – 1.10) 0.99 (0.89 – 1.10)
rs3217862 1,321 -- 0.95 (0.83 – 1.08) 0.95 (0.83 – 1.08) 0.95 (0.84 – 1.08) 0.95 (0.83 – 1.07)
rs3217863 409 -- 1.05 (0.88 – 1.26) 1.05 (0.88 – 1.26) 1.05 (0.89 – 1.25) 1.08 (0.91 – 1.28)
rs3217869 474 -- 1.02 (0.93 – 1.13) 1.02 (0.93 – 1.13) 1.01 (0.92 – 1.10) 1.02 (0.93 – 1.10)
rs3217901 5,419 -- 1.03 (0.93 – 1.13) 1.03 (0.93 – 1.13) 1.01 (0.93 – 1.10) 1.01 (0.93 – 1.10)
rs3217906 415 -- 1.03 (0.92 – 1.14) 1.03 (0.92 – 1.14) 1.02 (0.92 – 1.14) 1.02 (0.92 – 1.13)
rs3217916 2,869 -- 0.92 (0.83 – 1.02) 0.92 (0.83 – 1.02) 0.94 (0.85 – 1.04) 0.95 (0.87 – 1.03)
rs3217925 2,966 -- 0.91 (0.81 – 1.01) 0.91 (0.81 – 1.01) 0.92 (0.83 – 1.01) 0.94 (0.85 – 1.02)
rs3217926 44 1.03 (0.89 – 1.20) 0.98 (0.89 – 1.08) 0.99 (0.92 – 1.08) 0.99 (0.91 – 1.07) 0.99 (0.91 – 1.07)
rs1049612 1,079 1.04 (0.90 – 1.20) -- 1.04 (0.90 – 1.20) 0.99 (0.88 – 1.12) 1.03 (0.93 – 1.13)
rs3217933 238 0.95 (0.80 – 1.12) 1.09 (0.97 – 1.21) 1.04 (0.95 – 1.14) 1.04 (0.95 – 1.14) 1.04 (0.95 – 1.14)
rs3217936 1,952 -- 0.91 (0.82 – 1.01) 0.91 (0.82 – 1.01) 0.94 (0.85 – 1.02) 0.94 (0.87 – 1.03)
CDKN1B rs3759216 N.A. 1.05 (0.91 – 1.21) 1.02 (0.93 – 1.13) 1.03 (0.95 – 1.12) 1.03 (0.95 – 1.11) 1.02 (0.94 – 1.10)
rs3759217 366 1.06 (0.86 – 1.31) 1.14 (0.99 – 1.32) 1.11 (0.99 – 1.26) 1.11 (0.99 – 1.25) 1.12 (0.99 – 1.26)
rs34330 2,243 0.94 (0.80 – 1.11) 0.91 (0.81 – 1.02) 0.92 (0.84 – 1.01) 0.92 (0.84 – 1.01) 0.92 (0.84 – 1.01)
rs2066827 404 -- 0.84 (0.75 – 0.94) 0.84 (0.75 – 0.94) 0.84 (0.76 – 0.94) 0.85 (0.77 – 0.94)
rs34329 2,134 1.12 (0.96 – 1.30) 1.00 (0.90 – 1.11) 1.04 (0.95 – 1.13) 1.03 (0.95 – 1.13) 1.03 (0.95 – 1.12)
rs3093736 68 1.07 (0.72 – 1.59) 0.97 (0.75 – 1.26) 1.00 (0.80 – 1.24) 0.99 (0.80 – 1.23) 0.99 (0.80 – 1.23)
rs7330 1,616 1.05 (0.91 – 1.21) 1.01 (0.92 – 1.11) 1.02 (0.94 – 1.10) 1.02 (0.94 – 1.10) 1.02 (0.94 – 1.11)
rs1420023 1,194 0.84 (0.68 – 1.05) 0.98 (0.84 – 1.14) 0.94 (0.83 – 1.06) 0.93 (0.82 – 1.06) 0.93 (0.82 – 1.06)
rs34322 3,459 0.98 (0.85 – 1.13) -- 0.98 (0.85 – 1.13) 0.97 (0.84 – 1.12) 1.02 (0.94 – 1.11)
CDK2 rs2069391 N.A. 1.16 (0.89 – 1.52) -- 1.16 (0.89 – 1.52) 1.15 (0.88 – 1.50) 1.21 (1.02 – 1.43)
rs2069408 4,443 0.94 (0.80 – 1.09) 0.94 (0.84 – 1.04) 0.94 (0.86 – 1.02) 0.93 (0.85 – 1.01) 0.93 (0.85 – 1.01)
rs2069414 1,378 1.55 (1.18 – 2.04) -- 1.55 (1.18 – 2.04) 1.58 (1.20 – 2.09) 1.58 (1.20 – 2.09)
rs1045435 461 1.17 (0.90 – 1.53) 1.14 (0.97 – 1.34) 1.15 (1.00 – 1.32) 1.14 (1.00 – 1.31) 1.14 (1.00 – 1.31)
rs11171710 1,918 1.06 (0.92 – 1.22) -- 1.06 (0.92 – 1.22) 1.07 (0.93 – 1.23) 1.05 (0.95 – 1.17)
rs17528736 440 1.15 (0.78 – 1.70) -- 1.15 (0.78 – 1.70) 1.13 (0.77 – 1.67) 1.23 (1.01 – 1.48)
rs773108 1,393 0.93 (0.80 – 1.08) -- 0.93 (0.80 – 1.08) 0.92 (0.79 – 1.08) 0.92 (0.85 – 1.00)
CDK4 rs2069506 N.A. -- 0.99 (0.89 – 1.09) 0.99 (0.89 – 1.09) 1.00 (0.92 – 1.08) 0.99 (0.90 – 1.09)
rs2069502 1,811 1.02 (0.88 – 1.18) -- 1.02 (0.88 – 1.18) 1.00 (0.92 – 1.08) 1.00 (0.89 – 1.12)
rs2270777 491 0.90 (0.78 – 1.03) 1.03 (0.93 – 1.13) 0.99 (0.91 – 1.07) 0.99 (0.91 – 1.07) 0.99 (0.91 – 1.07)
rs2072052 1,563 1.03 (0.89 – 1.19) -- 1.03 (0.89 – 1.19) 1.00 (0.92 – 1.08) 1.03 (0.89 – 1.20)
RB1 rs1981434 N.A. -- 0.97 (0.87 – 1.08) 0.97 (0.87 – 1.08) 0.97 (0.88 – 1.08) 0.98 (0.90 – 1.07)
rs2854345 10,082 -- 1.00 (0.89 – 1.12) 1.00 (0.89 – 1.12) 1.00 (0.88 – 1.12) 1.00 (0.88 – 1.12)
rs4151467 28,687 1.07 (0.78 – 1.45) -- 1.07 (0.78 – 1.45) 1.09 (0.80 – 1.48) 1.09 (0.80 – 1.48)
rs7329938 12,056 1.08 (0.87 – 1.33) -- 1.08 (0.87 – 1.33) 1.08 (0.88 – 1.33) 1.09 (0.88 – 1.35)
rs4151510 13,196 1.08 (0.88 – 1.34) -- 1.08 (0.88 – 1.34) 1.08 (0.95 – 1.24) 1.10 (0.89 – 1.36)
rs399413 3,394 -- 1.02 (0.91 – 1.14) 1.02 (0.91 – 1.14) 0.96 (0.88 – 1.06) 1.00 (0.91 – 1.09)
rs4151540 7,091 -- 0.96 (0.86 – 1.07) 0.96 (0.86 – 1.07) 0.94 (0.85 – 1.03) 0.96 (0.86 – 1.07)
rs9568036 16,276 1.03 (0.89 – 1.19) -- 1.03 (0.89 – 1.19) 1.03 (0.89 – 1.19) 1.00 (0.91 – 1.10)
rs198604 12,127 1.00 (0.84 – 1.17) -- 1.00 (0.84 – 1.17) 1.00 (0.85 – 1.18) 0.98 (0.89 – 1.07)
rs4151551 1,376 1.10 (0.85 – 1.41) 1.06 (0.90 – 1.25) 1.07 (0.93 – 1.23) 1.06 (0.93 – 1.22) 1.06 (0.93 – 1.22)
rs2854344 12,254 0.97 (0.73 – 1.28) 0.81 (0.66 – 0.99) 0.87 (0.74 – 1.02) 0.88 (0.75 – 1.04) 0.88 (0.75 – 1.04)
rs425834 14,800 -- 1.04 (0.80 – 1.36) 1.04 (0.80 – 1.36) 1.05 (0.81 – 1.37) 1.05 (0.81 – 1.37)
rs4151611 35,438 -- 0.91 (0.72 – 1.14) 0.91 (0.72 – 1.14) 0.90 (0.71 – 1.13) 0.89 (0.71 – 1.13)
rs4151620 1,128 -- 1.00 (0.85 – 1.17) 1.00 (0.85 – 1.17) 1.04 (0.90 – 1.20) 1.02 (0.87 – 1.20)
rs3092904 2,422 -- 0.98 (0.87 – 1.10) 0.98 (0.87 – 1.10) 0.96 (0.86 – 1.07) 0.97 (0.89 – 1.07)
rs4151636 5,253 -- 0.93 (0.74 – 1.17) 0.93 (0.74 – 1.17) 0.92 (0.73 – 1.16) 0.92 (0.73 – 1.15)
rs990814 2,843 1.00 (0.85 – 1.17) -- 1.00 (0.85 – 1.17) 1.01 (0.86 – 1.18) 0.98 (0.90 – 1.08)
CDKN2D rs3218222 N.A. -- 1.02 (0.91 – 1.14) 1.02 (0.91 – 1.14) 1.01 (0.91 – 1.12) 1.01 (0.91 – 1.12)
rs1465702 1,951 -- 1.10 (0.88 – 1.39) 1.10 (0.88 – 1.39) 1.05 (0.86 – 1.29) 1.05 (0.86 – 1.29)
rs1465701 210 1.15 (0.97 – 1.35) -- 1.15 (0.97 – 1.35) 1.16 (0.98 – 1.36) 1.16 (0.98 – 1.36)
rs17677316 1,399 0.90 (0.76 – 1.06) -- 0.90 (0.76 – 1.06) 0.89 (0.75 – 1.05) 0.89 (0.75 – 1.05)
CCNE1 rs997669 N.A. 0.97 (0.84 – 1.13) 1.07 (0.97 – 1.18) 1.04 (0.96 – 1.13) 1.04 (0.96 – 1.13) 1.04 (0.96 – 1.13)
rs3218036 1,201 -- 1.11 (1.00 – 1.23) 1.11 (1.00 – 1.23) 1.07 (0.98 – 1.17) 1.12 (1.01 – 1.24)
rs3218038 211 -- 1.03 (0.80 – 1.33) 1.03 (0.80 – 1.33) 1.02 (0.84 – 1.24) 1.02 (0.79 – 1.32)
rs1406 9,217 0.99 (0.84 – 1.18) -- 0.99 (0.84 – 1.18) 0.98 (0.89 – 1.08) 1.00 (0.92 – 1.10)
rs3218076 158 -- 1.02 (0.91 – 1.13) 1.02 (0.91 – 1.13) 1.01 (0.92 – 1.11) 1.00 (0.92 – 1.10)

Bold indicates p < 0.05