Table 1. Ion channel gene expression in NSCs with and without amiodarone HCl treatment compared to similarly treated dopaminergic neurons.
Category | Gene | Treated NSC | Untreated NSC | Treated DA Neuron | Untreated DA Neuron |
H ion transporters | ATP6V1A | 1155.9 | 1093.8 | 2621.5 | 2441.8 |
ATP6V1B2 | 385.4 | 331 | 724.8 | 438.2 | |
ATP6V0D1 | 3355 | 2760.4 | 2920.7 | 2452.5 | |
ATP5B | 7030.3 | 5745.1 | 5217.1 | 4313.4 | |
ATP6V0A2 | 190.2 | 163 | 131.3 | 108 | |
SLC2A11 | 22.8 | 31.1 | .9 | 34.9 | |
SLC35B1 | 1769.8 | 1380.4 | 1450.4 | 1122.8 | |
SLC2A1 | 1274.8 | 1574.5 | 87.1 | 86.7 | |
Amine transporters | SLC1A2 | 15.7 | 21.3 | 809.7 | 681 |
SLC1A3 | 552.1 | 433.5 | 2926 | 2578.1 | |
SLC6A3 | −1.2 | 4.8 | −3.4 | 10.5 | |
SLC6A9 | 329.2 | 251.5 | 36570.5 | 489.3 | |
SLC6A12 | 9.6 | 7.4 | 10.8 | 10.4 | |
ATP1A1 | 586.9 | 615.7 | 426.9 | 341.4 | |
ATP1A1 | 786.4 | 725.1 | 471 | 399.4 | |
Cl channels | CLCN6 | 349.8 | 311.8 | 998.5 | 745.9 |
CLCN7 | 1305.5 | 903.2 | 1261 | 1058.4 | |
CLCN3 | 566.5 | 440.4 | 541.2 | 497.2 | |
CLCN2 | 41.6 | 30.2 | 24 | 21.7 | |
CLIC1 | 122.2 | 94.9 | 22.9 | 18 | |
Voltage gated Na channels | SCN9A | 1.9 | 2.6 | 245.7 | 175.1 |
SCN1A | −0.5 | 7.6 | 115.6 | 110.2 | |
SCN3A | 5.7 | 6.3 | 60.4 | 72.3 | |
Amiloride sensitive Na channels | ACCN1 | 16.5 | 15.4 | 387.4 | 360.1 |
ACCN3 | 11 | 5.1 | 35.7 | 38.1 | |
ACCN2 | 185.7 | 167.4 | 862.7 | 837.1 | |
Rectifier K channels | KCND2 | 2.3 | 8.9 | 269.9 | 225.5 |
KCNQ2 | 138.1 | 137 | 1753.5 | 1378.2 | |
KCNC4 | 4.5 | 5.8 | 58.7 | 38.7 | |
KCNJ4 | 15.9 | 11.6 | 66.1 | 64.3 | |
KCNQ3 | 3.4 | 5.5 | 23.2 | 25.4 | |
KCNG1 | 150.4 | 92.7 | 351 | 365 | |
KCNF1 | 189.2 | 152 | 479.7 | 457.6 | |
KCNJ11 | 13.5 | 17.7 | 44.4 | 26.5 | |
KCNJ6 | 317.3 | 271.5 | 297.7 | 256.7 | |
KCNQ2 | 919.6 | 796.2 | 434.4 | 420.4 | |
Delayed rectifier K channels | KCNA5 | −4.2 | 0.4 | 99.9 | 84 |
KCNS1 | 5.2 | 2.2 | 20.3 | 39.9 | |
KCNH2 | 25.6 | 32 | 165.6 | 151.9 | |
KCNB1 | 32.8 | 34.2 | 145.4 | 111.5 | |
KCNB2 | 25 | 28.7 | 94.5 | 79.1 | |
KCNH2 | 11.2 | 5.8 | 21 | 14.2 | |
Ca activated K channels | KCNN1 | 6.5 | 0.6 | 48.4 | 28.9 |
KCNN3 | 0.7 | 6.3 | 181.7 | 127.1 | |
KCNN2 | 15.8 | 12.3 | 55.6 | 50.1 | |
KCNMB1 | 62.9 | 60.4 | 44.8 | 72.6 | |
Calcium channels | CACNB2 | 7.8 | 12 | 155.2 | 156.9 |
CACNG2 | 2.5 | 11.5 | 123.8 | 115.6 | |
CACNA1A | 2 | 10.1 | 64.4 | 62.6 | |
CACNA1C | 25.9 | 29.3 | 146.9 | 138.8 | |
CACNA1H | 122.7 | 87.8 | 268.9 | 220.4 |