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. 2009 Sep 23;4(9):e7142. doi: 10.1371/journal.pone.0007142

Figure 3. Resolution of PR8 influenza virus infection is enhanced in mice treated with PCN prior to infection.

Figure 3

A) Viral recovery from the lungs of mice treated with PCN 9x prior to infection is significantly enhanced; **, P = 0.002; dotted line is limit of assay detection. B) PCN-treated mice did not lose body weight during resolution of subsequent influenza virus infection; **, P = 0.0024; ***, P<0.0001. No lung damage in association with the PCN treatment is evident, as indicated by the equivalent serum albumin (C) and lactate dehydrogenase (D) levels observed in the in the BALF of PCN treated mice (clear bars) and PBS treated mice (shaded bars) prior to infection. Following infection, serum albumin and LDH levels in the recovered BALF of PCN treated mice (clear bars with lines) is significantly less than that detected in the PBS treated mice (shaded bar with lines); **, P = 0.003.