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. 2009 Sep 22;4(9):e7121. doi: 10.1371/journal.pone.0007121

Figure 2. IL-10 gene and protein expression in VMD2-IL-10 transgenic mice.

Figure 2

A, Gene expression of IL-10 is upregulated in the eye, testes, brain, sciatic nerve, and spinal cord of Tg+ sick animals compared to tissues from Tg− littermates, as determined by quantitative real-time RT-PCR. B, IL-10 protein levels from the cerebrospinal fluid (CSF) significantly increase in correlation with disease progression (p≤0.002 for each stage of disease), as determined by IL-10 specific ELISA. Plasma levels of IL-10 are not elevated in Tg+ mice.