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. 2009 Sep 22;4(9):e7121. doi: 10.1371/journal.pone.0007121

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Dace et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Flow cytometry of spleens from animals reveal a slightly decreased presence of F4/80+ macrophages (p<0.001) and increased CD3+ T cells (p = 0.008) in Tg+ sick mice compared to Tg− littermates. B, Flow cytometry of sciatic nerve tissue from mice reveal a significant infiltration of F4/80+ (p = 0.001) and CD11b+ cells (p = 0.002) into the sciatic nerve of Tg+ sick mice compared to Tg− mice. C, Flow cytometry of spinal cord tissue reveals an increase in F4/80+ cells (p = 0.002) into the spinal cord of Tg+ sick mice. Sciatic nerve sections (200X) from mice were stained with APC conjugated anti-F4/80 antibody reveal no infiltration of F4/80+ macrophages in D, wild-type or E, Tg+ healthy animals. Significant infiltration of macrophages is seen in F, Tg+ sick early mice. Decreased macrophages and loss of tissue are observed in sciatic nerves from G, Tg+ sick late mice.