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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Crit Care Med. 2009 Jun;37(6):2000–2009. doi: 10.1097/CCM.0b013e3181a001ae

Figure 4. Monocyte Cytokine Responses to Treatment with Nuclear, Cytoplasmic and Mitochondrial Components of Necrotic Cells.

Figure 4

(A) Six hrs after exposure to increasing titrations of HepG2 subcellular fractions, dose-dependent monocyte IL-8 release was limited to the mitochondrial compartment, particularly the membrane fraction. (B) Monocyte IL-8 release was comparable when treated with mitochondria derived from HepG2 cells or human liver homogenates. LPS (10 ng/ml) was used as a positive control.