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. 2009 Aug;11(4):414–422. doi: 10.1215/15228517-2008-096

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Copyright © 2009 by the Society for Neuro-Oncology

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Fig. 2. — RLGS spot 1D05 is frequently altered in higher-grade meningiomas, and the alteration is tumor-type specific. (A) A magnified section of an RLGS profile from normal human leptomeninges showing the presence of 1D05 (black arrow) and the adjacent spot, 1D06 (white arrow). (B and C) Representative RLGS sections from a grade II (B) and a grade III (C) meningioma showing loss of 1D05 but not 1D06. (D) The percentage of tumors with 1D05 methylation in 14 different types of tumors showed that the aberrant methylation of this locus is tumor-type specific. Abbreviations: BRE, breast carcinoma; CER, cervical carcinoma; CLL, chronic lymphocytic leukemia; CLN, colorectal carcinoma; ABT, adult brain tumors; HN_P, primary head and neck squamous cell carcinoma; HN_M, metastatic head and neck squamous cell carcinoma; AML, acute myeloid leukemia; LNG, non-small-cell lung carcinoma; MB, medulloblastoma; PNET, primitive neuroectodermal tumor; TST_ NS, nonseminomatous testicular germ cell tumor; TST_S, semi-nomatous testicular germ cell tumor. Numbers in parentheses are numbers of samples for that tumor type.