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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Anesthesiology. 2008 Dec;109(6):978–988. doi: 10.1097/ALN.0b013e31818e3b1b

Figure 4.

Figure 4

Pontine reticular formation microinjection of drugs that alter GABA levels significantly changed isoflurane induction time and breathing rate. A. The GABA synthesis inhibitor 3-mercaptopropionic acid (3-MPA) significantly (P < 0.02) decreased time to loss of righting response (LoRR). B. Pontine reticular formation microinjection of the GABA uptake inhibitor nipecotic acid (NPA) significantly (P < 0.01) increased the amount of time required for isoflurane to cause a loss of the righting response. C. Rate of breathing was not significantly altered by 3-MPA. D. Nipecotic acid significantly (P < 0.002) increased rate of breathing.