Table 2. Changes in Iqgap Gene/mRNA Expression Level in Neoplasms^‡.

Tissue Comparison	IQGAP	Species	Method	Neoplasm	Expression Change	Refs
Cancer vs Normal	Iqgap1	Human	Array	Colorectal	+	[73]
				Glioma	+	[97]
			RT-PCR	Glioma	+	[97]
				Lung	+	[72]
		Mouse	Array	Prostate	+	[74]
	Iqgap2	Human	Array	Colorectal	+	[78]
				Prostate	+	[79]
Aggressive vs Less Aggressive Cancer†	Iqgap1	Human	Array	Glioma	+	[88]a
		Mouse	Array	Medulloblastoma	+	[98]b
				Melanoma	+	[90]c
	Iqgap2	Human	Array	Prostate	-	[77]d
		Mouse	Array	Prostate	-	[74]e
	Iqgap3	Human	Array	Colorectal	-	[99]f

⁺increased expression;

^-decreased expression.

^†Aggressive vs less aggressive cancer is defined by a decrease in long-term survival^a,f, an increase in the likelihood of metastasis^b,c,e or a decline in tumor responsiveness to hormone therapy^d.

^‡Only published studies with primary tissue are included. Data with cultured cell lines have been omitted.