Table 3. Changes in IQGAP Protein Expression Level in Neoplasms^‡.

Tissue Comparison	IQGAP	Species	Method	Neoplasm	Expression Change	Refs
Cancer vs Normal	IQGAP1	Human	IHC	Colorectal	+	[80]
			MS	Squamous Cell (Head and Neck)	+	[82]
			WB	Astrocytoma	+	[81]
			WB	Breast	+	[23]
	IQGAP2	Human	IHC	Gastric	-	[76]
		Mouse	IHC/WB	Liver	-	[47]
Aggressive vs Less Aggressive Cancer†	IQGAP1	Human	IHC	Gastric	+	[83]a
				Glioma	+	[88]b
				Lung	+	[100]c
				Ovary	+	[84]d
			IHC/WB	Glioma	+	[87]e

⁺increased expression;

^-decreased expression.

^†Aggressive vs less aggressive cancer is defined by a decrease in long-term survival^a,b,d, an increase in the likelihood of metastasis^c,e.

^‡Only published studies with primary tissue are included. Data with cultured cell lines have been omitted.

Abbreviations: IHC, immunohistochemistry; WB, western blot; MS, mass spectrometry.