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. Author manuscript; available in PMC: 2010 Jul 9.
Published in final edited form as: J Med Chem. 2009 Jul 9;52(13):3829–3845. doi: 10.1021/jm801420y

Table 1.

Hh-Gli pathway inhibitors in clinical and preclinical studies.*

Compound Target Stage of Development
Cyclopamine (3)144 Smo Preclinical/Clinical
KAAD-Cyclopamine (14)97 Smo Preclinical
18 101 Smo Preclinical
26 13 Smo Phase I
54 89 Smo Halted after Phase I
7714, 114 Smo Phase I
9665, 123 Smo Preclinical
101 108 Smo Phase I/II
128 140 Gli Preclinical
*

as of December 2008.