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Diminished antinociceptive efficacy of WIN 55,212-2 (WIN) over time in uninjured rats (n = 7/group). Response latencies (in seconds) of hindpaw to noxious heat stimulus were measured in uninjured rats (a) before and (b) 30 min after injection of either WIN (0.3, 1, or 3 mg/kg) or vehicle. Rats were injected twice a day but tested only after first daily injection. Data are shown as mean ± standard error of the mean.
