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Dose-response to WIN 55,212-2 (WIN) 30 min after injection in uninjured rats (n = 7/group). Vertical axis is percent maximum possible effect (MPE) and horizontal axis is dose of WIN. On day 1, 50% percent antinociceptive (A50) dose of WIN was 1.1 mg/kg; on day 5, A50 dose was 15.1 mg/kg. Data are shown as mean ± standard error of the mean.
