Table.
Qualitative Evaluation of Increases in Cellular Glycogen
| Structure | Age | |||||
|---|---|---|---|---|---|---|
| 1 Month | 3 Months | 6 Months | 9 Months | 12 Months | 15 Months | |
| Brainstem and spinal cord motor nuclei | 3+ | 4+ | 4+ | 4+ | 4+ | 5+ |
| Brainstem sensory nuclei | 2+ | 3+ | 3+ | 3+ | 3+ | 3+ |
| Brainstem white matter | 1+ | 2+ | 3+ | 3+ | 3+ | |
| Dorsal root ganglion neurons | 2+ | 3+ | 4+ | 4+ | 4+ | 4+ |
| Striatum, neurons | 1+ | 1–2+ | 2+ | |||
| Striatum, glia and small vessels | 0–1+ | 1–2+ | 2+ | 2–3+ | 3+ | |
| Thalamus, neurons | 1+ | |||||
| Thalamus, glia and small vessels | 0–1+ | 1–2+ | 2+ | 2–3+ | 3+ | |
| Cerebral neocortex, neurons | 1+ | 1–2+ | 2+ | |||
| Cerebral cortical white matter | 1+ | 2+ | 3+ | 3–4+ | 4+ | |
| Rostral migratory stream | 2+ | 3+ | 3+ | 4+ | 4+ | 4+ |
| Olfactory bulb | 1+ | 2+ | 2+ | 3+ | 3+ | 4+ |
| Hippocampal pyramidal neurons | 1+ | |||||
| Hippocampal interstitial neurons | 1+ | 1–2+ | 2+ | |||
| Cerebellar Purkinje neurons | 1+ | |||||
| Cerebellar Golgi radial glia | 1+ | 2+ | 3+ | 3+ | 4+ | |
| Cerebellar nuclei | 2+ | 2+ | 3+ | 3+ | 3+ | |
| Meningeal cells and large vessels | 1+ | 2+ | 3+ | 3+ | 4+ | |
Glycogen per cell was evaluated qualitatively in Pompe model mice of various ages on a 0 to 5+ scale based on visual judgment of PAS staining intensity in histological sections.