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Inhibition constants for purified MTAN activity, cellular MTAN activity, and autoinducer (AI) production determined as described in METHODS.
| R-group | Purified enzyme inhibition Ki*, pM | Cellular MTAN Inhibition IC50, nM | AI Inhibition IC50, nM | |
|---|---|---|---|---|
| BB170 (ai1−ai2+) | BB120 (ai1+ai2+) | |||
| MT- (7) | 73 ± 5 | 27 ± 4 | 0.94 ± 0.13 | 10.5 ± 2.6 |
| EtT- (8) | 70 ± 4 | 31 ± 7 | 11.0 ± 2.0 | 14.0 ± 2.0 |
| BuT- (9) | 208 ± 46 | 6 ± 1 | 1.4 ± 0.3 | 1.0 ± 0.2 |
