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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Trends Analyt Chem. 2007 Jun 1;26(6):625–636. doi: 10.1016/j.trac.2007.02.009

Figure 5.

Figure 5

Metabolomics-type approach for the analysis of drug metabolites in bio-fluids. The data shown here was obtained by applying principle component analysis to the LC-MS data obtained from urine of both control rats and rats dosed (with GSK-X). The paired numbers for each data point represent retention time (top smaller number) and mass (bottom higher number). The bold cross in the circle indicates the metabolite (retention time 6.2 min and mass of 319.13) responsible for the clustering of control and dosed groups (Reproduced with permission from [51]; © 2003, John Wiley & Sons Limited).