Table 2.
Characteristics of the MrOS Cohort [Mean ± SD or N (%)] by Category of Estimated Change in FN BMD*
| Maintenance of BMD† [N = 1149 (24.3%)] | Expected loss of BMD‡ [N = 2982 (63.2%)] | Accelerated loss of BMD§ [N = 589 (12.5%)] | p¶ | |
| Age (yr) | 72.2 ± 5.1 | 72.9 ± 5.5 | 75.4 ± 5.9 | <0.0001 |
| Weight (kg) | 85.5 ± 13.5 | 82.7 ± 12.6 | 83.3 ± 14.1 | <0.0001 |
| Height (cm) | 174.8 ± 6.9 | 174.5 ± 6.7 | 173.6 ± 7.0 | 0.001 |
| Total body fat mass (kg) | 22.7 ± 7.2 | 21.3 ± 6.8 | 21.9 ± 7.5 | <0.0001 |
| Total body lean mass (kg) | 59.3 ± 7.6 | 58.0 ± 7.2 | 57.6 ± 7.5 | <0.0001 |
| BMI (kg/m2) | 28.0 ± 3.9 | 27.2 ± 3.6 | 27.6 ± 4.2 | <0.0001 |
| White race | 1014 (88.3) | 2704 (90.7) | 537 (91.2) | 0.043 |
| History of fracture | 621 (54.1) | 1672 (56.1) | 331 (56.2) | 0.4734 |
| Smoking status | ||||
| Never | 428 (37.3) | 1166 (39.1) | 239 (40.6) | 0.073 |
| Former | 696 (60.6) | 1718 (57.6) | 326 (55.4) | |
| Current | 25 (2.2) | 97 (3.3) | 24 (4.1) | |
| Alcohol use | ||||
| None | 357 (31.1) | 1008 (33.8) | 213 (36.2) | 0.153 |
| Light | 641 (55.8) | 1633 (54.8) | 313 (53.2) | |
| Heavy/moderate | 150 (13.1) | 338 (11.4) | 62 (10.5) | |
| Baseline femoral neck BMC (g) | 4.588 ± 0.833 | 4.431 ± 0.726 | 4.476 ± 0.818 | <0.0001 |
| Baseline femoral neck BMD (g/cm2) | 0.803 ± 0.137 | 0.779 ± 0.120 | 0.795 ± 0.136 | <0.0001 |
| Change in femoral neck BMD (%) | 1.48% (1.41) | −1.99% (1.28) | −6.62% (2.46) | <0.0001 |
| Baseline femoral neck area (cm2) | 5.72 (0.45) | 5.69 (0.41) | 5.64 (0.50) | 0.003 |
| Change in femoral neck area (%) | 0.39% (0.68) | 0.45% (0.63) | 0.48% (0.46) | 0.020 |
* Change in BMD is estimated from clinical center adjusted mixed models.
† Change ≥0: no change or increase.
‡ Change between no change (0) and 1 SD below mean change; cut-points are 0 to –0.034 g/cm2.
§ Change ≥1 SD below mean change; at least –0.034 g/cm2 loss.
¶ p value from ANOVA (continuous variables) or χ2 test (categorical variables).