Figure 6. 3D representation of the surface and interior of an HIV-infected macrophage (animation is presented in Video S10).

(A) Sections that would appear to contain “filopodia” when imaged by transmission electron microscopy of individual sections can actually correspond to large wavelike membrane processes as in this example. The virions are shown in red. (B, C) Schematic side (B) and front (C) views of these surface protrusions shown to indicate how bending and folding back of the extensions onto the surface of the cell could trap the contents of the aqueous environment within the invaginated folds of the membrane, and allow creation of viral compartments.