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. Author manuscript; available in PMC: 2009 Sep 26.
Published in final edited form as: Circ Res. 2008 Aug 28;103(7):690–693. doi: 10.1161/CIRCRESAHA.108.184663

Figure 1.

Figure 1

KLF2 heterozygous mice develop more atherosclerosis. Male littermate ApoE−/− and KLF2+/−/ApoE−/− mice at 6 weeks of age were fed a high fat, high cholesterol diet for 20 weeks. Aortas were harvested and Sudan IV stained for lipid. A, Two representative pairs of fixed and stained whole aortas. B, Percent lesion area of the entire isolated aorta area was calculated. ApoE−/− 27.3±9.9% (n=12), and KLF2+/−/ApoE−/− 35.9±10.2% (n=14). C, Two representative pairs of fixed and stained aortas en face. D, Percent lesion area of the entire aorta surface area was calculated. ApoE−/− 17.6±5.4% (n=12), and KLF2+/−/ApoE−/− 24±6.3% (n=14). K2+/− = KLF2+/−.