Table 3. Univariate Cox proportional hazards regression for progression-free survival (PFS) and overall survival (OS).

	Patients		PFS			OS
Marker	n	%	HR	95% CI	P	HR	95% CI	P
TP53 mutation
Absent	72	63	1.00			1.00
Present	43	37	0.85	0.58–1.26	0.4	0.88	0.56–1.37	0.6
Kras mutation
Absent	80	68	1.00			1.00
Present	37	32	0.91	0.60–1.36	0.6	0.76	0.48–1.21	0.2
MSI
Absent	114	98	1.00			1.00
Present	2	2	0.36	0.05–2.62	0.3	0.40	0.06–2.92	0.4
MTHFR 677
CC	43	37	1.00			1.00
CT	54	47	0.81	0.53–1.24	0.3	1.10	0.68–1.76	0.7
TT	19	16	1.05	0.61–1.81	0.9	1.35	0.75–2.45	0.3
CT and TT	73	63	0.87	0.59–1.29	0.5	1.16	0.75–1.81	0.5
ERCC1-118
CC	10	9	1.00			1.00
CT	64	56	2.68	1.15–6.23	0.02	1.88	0.75–4.71	0.2
TT	41	35	2.54	1.07–6.04	0.04	1.55	0.60–4.00	0.4
CT and TT	105	91	2.62	1.14–6.02	0.02	1.74	0.70–4.30	0.2
XRCC1-399
GG	39	34	1.00			1.00
AG	61	53	0.57	0.28–1.19	0.1	0.92	0.58–1.45	0.7
AA	15	13	1.01	0.39–2.60	1.0	0.52	0.24–1.14	0.1
AG and AA	76	66	0.66	0.34–1.28	0.2	0.83	0.53–1.29	0.4