Table 3. TNF promoter haplotypes in PTLD and control subjects.
|
TNF promoter polymorphism
|
Transplant subjects without PTLD (n=64) | Transplant subjects with PTLD (n=42) | Odds ratio | Healthy control subjects (n=176) | Odds ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | −1031 | −863 | −857 | −307 | −237 | freq % | freq % | (95% CI) | P-valuea | freq % | (95% CI) | P-valuea,b |
| 1 | T | C | C | G | G | 83 | 62 | 2.96 (1.2–7.29) | 0.02* | 76 | 0.52 (0.26–1.07) | 0.08 |
| 2 | T | C | C | A | G | 36 | 31 | 1.25 (0.54–2.87) | 0.67 | 37 | 0.76 (0.37–1.56) | 0.59 |
| 3 | C | A | C | G | G | 14 | 50 | 0.16 (0.06–0.4) | 0.0001* | 26 | 2.91 (1.46–5.8) | 0.003* |
| 4 | T | C | T | G | G | 9 | 19 | 0.43 (0.14–1.37) | 0.23 | 15 | 1.38 (0.57–3.26) | 0.48 |
| 5 | C | C | C | G | A | 14 | 2 | 6.70 (0.81–55.10) | 0.08 | 9 | 0.24 (0.03–1.90) | 0.2 |
| 6 | C | C | C | G | G | 3 | 7 | 0.41 (0.06–2.62) | 0.38 | 8 | 0.89 (0.24–3.25) | 1 |
Abbreviations: CI=confidence interval; freq=frequency; TNF=tumour necrosis factor.
Data are given as frequency with absolute numbers in parentheses.
a
Fisher's exact two-sided P-value (not adjusted for multiple testing).
b
Comparison between post-transplant lymphoproliferative disease (PTLD) and healthy control groups; *significant P-value, P<0.05.