Table 3.
Likelihood Ratio Tests Evaluating the Additive Effect of Each of 2 Predictors Given That the Other Predictor Is in the Model After Adjusting for Age, Sex, and Education
| Predictor 1 | Predictor 2 | Additive Effect (P Value) | |||
|---|---|---|---|---|---|
| Predictor 1 | Predictor 2 | ||||
| All Groupsa | MCI Onlyb | All Groupsa | MCI Onlyb | ||
| Hippocampal W score | NAA:Cr ratio | 54 (<.001) | 14 (.001) | 7.4 (.06) | 1.6 (.46) |
| mI:Cr ratio | 50 (<.001) | 14 (.001) | 18 (<.001) | 14 (.001) | |
| Cho:Cr ratio | 52 (<.001) | 15 (<.001) | 11 (.01) | 3.6 (.16) | |
| Log(WMH volume) | 54 (<.001) | 15 (<.001) | 18 (<.001) | 5.4 (.07) | |
| Cortical infarctionsc | … | 13 (.002) | … | 1.5 (.47) | |
| NAA:Cr ratio | mI:Cr ratio | 4.7 (.20) | 2.4 (.31) | 19 (<.001) | 15 (<.001) |
| Cho:Cr ratio | 7.7 (.053) | 1.5 (.46) | 13 (.005) | 2.6 (.27) | |
| Log(WMH volume) | 5.2 (.16) | 1.8 (.42) | 16 (.001) | 4.8 (.09) | |
| Cortical infarctionsc | … | 1.7 (.43) | … | 2.7 (.26) | |
| mI:Cr ratio | Cho:Cr ratio | 14 (.003) | 13 (.002) | 7.2 (.07) | 0.74 (.69) |
| Log(WMH volume) | 21 (<.001) | 16 (<.001) | 18 (<.001) | 5.7 (.06) | |
| Cortical infarctionsc | … | 13 (.001) | … | 1.2 (.56) | |
| Cho:Cr ratio | Log(WMH volume) | 9.0 (.03) | 2.5 (.28) | 14 (.002) | 4.6 (.10) |
| Cortical infarctionsc | … | 2.4 (.30) | … | 2.3 (.31) | |
| Log(WMH volume) | Cortical infarctionsc | … | 5.2 (.07) | … | 3.1 (.21) |
Abbreviations: Cho, choline; Cr, creatine; mI, myo-inositol; MCI, mild cognitive impairment; NAA, N-acetylaspartate; WMH, white matter hyperintensity; ellipses not reported.
a
Based on a 3-df χ2 test.
b
Based on a 2-df χ2 test.
c
Because absence of cortical infarctions was among the inclusion criteria for the cognitively normal group, the results among all 4 groups are not reported