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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Arch Neurol. 2008 Dec;65(12):1621–1628. doi: 10.1001/archneur.65.12.1621

Table 4.

MRI and 1H MRS Characteristics of MCI Subtypes and the Pattern of Imaging Abnormalities That Relate to AD or CVD

MCI Subtype Hippocampal
Volumes		 1H MRS,
mI:Cr Ratio		 Cortical
Infarctions		 Pattern
AD-Like CVD More Common
Single-domain aMCI Atrophy Elevated Less frequent Yes No
naMCI Normal Normal More frequent No Yes
Multiple-domain aMCI Mild atrophy Normal More frequent Some Yes

Abbreviations: AD, Alzheimer disease; aMCI, amnestic mild cognitive impairment (MCI); Cr, creatine; CVD, cerebrovascular disease; 1H MRS, proton magnetic resonance spectroscopy; mI, myo-inositol; MRI, magnetic resonance imaging; naMCI, nonamnestic MCI.