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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Shock. 2008 Oct;30(4):434–442. doi: 10.1097/SHK.0b013e3181673543

Figure 6. Mortality following CLP or peritoneal LPS administration is dependent on expression of PU.1 in peritoneal macrophages.

Figure 6

Figure 6

A. GM-CSF−/− mice received GM-CSF−/−/PU.1Negative macrophages (mAM cells) or GM-CSF−/−,/PU.1Positive macrophages (mAMPU.1+ cells) and WT mice received mAM cells, all by passive intraperitoneal transfusion (n= 15, 15, 18 per group, respectively). Twenty-four hours later, all mice underwent CLP and mortality was evaluated every 12 hr for 7 days. B. GM-CSF−/− and WT mice were injected with either mAM or mAMPU.1+ cells as above (A) (n=12 mice/group). Twenty-four hours later all mice received LPS by intraperitoneal injection and mortality was evaluated every 12 hr for 7 days.