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. Author manuscript; available in PMC: 2009 Nov 6.
Published in final edited form as: Mol Cell Endocrinol. 2008 Jul 9;294(1-2):19–28. doi: 10.1016/j.mce.2008.06.019

Fig. 5.

Fig. 5

Histological analysis of testes (A-C) and ovaries (D-F) from 6-week-old Inha-/-, Inha-/-Lhb-/-, and Lhb-/- mice (n ≥ 5 gonads of each sex and genotype). (A) Inha-/- testis predominantly containing tumor cells and hemorrhage (asterisk), with a smaller region of normal seminiferous tubules (S). In contrast, the testis of an age-matched Inha-/-Lhb-/- male (B) is filled with seminiferous tubules, and only two small tumor foci (asterisks) are readily apparent. (C) No tumor foci are present in Lhb-/- testes. (D) Inha-/- ovary with architecture almost entirely disrupted by numerous hemorrhagic cysts (arrows) and nodules of poorly differentiated neoplastic cells. In contrast, the ovaries from age-matched Inha-/-Lhb-/- (E) and Lhb-/- (F) females are non-hemorrhagic, intact, and contain multiple oocytes. Magnification: A: ×12.5; B: ×15.6; C: ×20; D: ×31.3; E: ×25; F: ×62.5.