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. Author manuscript; available in PMC: 2009 Nov 6.
Published in final edited form as: Mol Cell Endocrinol. 2008 Jul 9;294(1-2):19–28. doi: 10.1016/j.mce.2008.06.019

Fig. 7.

Fig. 7

Quantitative real-time PCR analysis of end-stage Inha-/- and Inha-/-Lhb-/- gonadal tumors (mean ± SEM, n ≥ 4 tumors from independent mice of each sex and genotype). (A) Double mutant testicular tumors demonstrated a significant decrease in the relative quantity (RQ) of Star (4.3-fold), Cyp11a1 (3.9-fold), Ccnd2 (3.5-fold), Cdkn1b (3.6-fold), Inhba (6.4-fold), and Inhbb (4.7-fold). (B) Double mutant ovarian tumors demonstrated a significant decrease in the expression of Cyp17a1 (4.5-fold) and a significant increase in the expression of Cdkn2b (2.8-fold). We also noted a trend toward increased expression of Cdkn1b (2.4-fold) in double mutant ovarian tumors. Ages of end-stage mice: Inha-/- males (8-13 wks) and females (12-19 wks); Inha-/-Lhb-/- males (13-18 wks) and females (18-53 wks). *p<0.05, **p<0.005, ***p<0.001 (Student's t-test).