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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Stem Cells. 2008 Jul 31;26(10):2644–2653. doi: 10.1634/stemcells.2008-0187

Figure 5.

Figure 5

Engraftment of transplanted stem cells. KATP channel-deficient cardiomyopathic hearts treated with ES, engineered to express the lacZ reporter transgene (ES(+)) demonstrated β-gal ([A], pink) nuclear expression with cellular coexpression of actinin ([A], green), along with Kir6.2 expression ([B], red) within otherwise KATP channel-deficient cardiomyocytes. Treated hearts had a significant increase in cells positive for Ki67 ([C, D], pink), a cellular marker for proliferation, and a decrease in interstitial fibrosis ([E]; [F], blue), compared with untreated hearts (ES(−)). In (A–C), blue indicates DAPI. *, p < .05 versus ES(−). Abbreviations: actinin, sarcomeric α-actinin; DAPI, 4′,6′-diamidino-2-phenylindole; ES, embryonic stem cell; β-gal, β-galactosidase.