Figure 6.
Ultrastructure in untreated versus treated cardiomyopathic hearts. Untreated Kir6.2-knockout cardiomyopathic hearts (ES(−)) displayed significant fibrosis and CBs (A), disorganized Mito (C), and a paucity of tight junctions (E). (B, D, F): In contrast, stem cell-treated hearts (ES(+)) demonstrated proper sarcomeric ultrastructure (B), dense mitochondrial clusters (D), and desmosome with tight junction formation ([F], arrowheads and arrows). Abbreviations: CB, contraction band; ES, embryonic stem cell; Mito, mitochondria.