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ES therapy produces favorable systemic outcome on morbidity and mortality. Exercise running capacity and workload evaluated by treadmill (A, B), overall fitness (C), and mortality (D) were all favorably affected by a 1-month-long treatment with ES (ES(+)) in KATP channel-null mutants mice despite the stress of continuous transverse aortic constriction. †, p < .05 versus Pre; *, p < .05 versus ES(−). Abbreviations: ES, embryonic stem cell; min, minutes; Pre, prestress.
