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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Curr Opin Struct Biol. 2009 Mar 14;19(2):203–208. doi: 10.1016/j.sbi.2009.02.004

Figure 3.

Figure 3

Structure of the 26S proteasome. (a) and (b) 3D reconstructions of the 26S proteasome, by single particle EM (reprinted with permission from [7] and [9]). (c) Comparison of the 20S-PAN complex with the 26S proteasome shows the similarity between the PAN ATPase complex (colored in gold) and the 19S base subunit (colored in gold) (reprinted with permission from [28]). The 20S-PAN complex may be used as a simpler model system to dissect the mechanism of substrates unfolding and translocation by the eukaryotic proteasomal ATPases.