. Author manuscript; available in PMC: 2010 May 15.

Published in final edited form as: Cancer Res. 2009 Apr 21;69(10):4217–4224. doi: 10.1158/0008-5472.CAN-08-4915

Table 3.

Association of high/moderate/low risk variable in BLyS SNPs rs1224141, rs12583006, and rsl 2428930 with NH

Samples	Number of subjects			OR (95% C.I.)^*	P-value^*	*Permutation-adjusted OR (95% CI)*⁺
	Low Risk	Moderate Risk	High Risk	OR (95% C.I.)^*	P-value^*	*Permutation-adjusted OR (95% CI)*⁺
Controls	52	315	108	REF	NA	NA
All NHL cases	35	244	155	1.57 (1.25, 1.97)	0.0001	1.43 (0.95, 1.54)
DLBCL cases	4	38	27	1.90 (1.21, 3.00)	0.006	1.69 (1.10, 2.07)
Follicular cases	7	68	38	1.59 (1.10, 2.29)	0.014	1.43 (0.90, 1.60)
CLL/SLL cases	14	66	36	1.24 (0.87, 1.77)	0.23	1.06 (0.68, 1.18)
B-cell NHL excluding CLL/SLL	11	106	65	1.74 (1.33, 2.27)	0.0001	1.61 (1.06, 1.74)

Odds ratios, 95% confidence intervals, and p-values generated assuming a log-additive effect between low-moderate-high risk coding for each case type independently versus the control subjects. All analyses adjusted for region, gender, and age.

⁺

Permutation results based upon 10,000 random permutations. Adjusted OR and p-values calculated using permutation methods.